Search results for "Veterinary drug"

Target analysis and retrospective screening of veterinary drugs, ergot alkaloids, plant toxins and other undesirable substances in feed using liquid …

2015

A comprehensive strategy combining a quantitative method for 77 banned veterinary drugs, mycotoxins, ergot alkaloids and plant toxins, and a post-target screening for 425 substances including pesticides and environmental contaminants in feed were developed using a QuEChERS-based extraction and an ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS). The quantitative method was validated after previous statistical optimisation of the main parameters governing ionisation, and presented recoveries ranging, in general, from 80 to 120%, with a precision in terms of Relative Standard Deviation (RSD) lower than 20%. The full-scan accurate mass data…

Veterināro preparātu atlieku noteikšana ar masspektrometrijas metodēm

2004

Analysis of veterinary drugs residues using masspectrometric methods. Bartkevičs V.. supervisors Dr.chem,J.Ģībietis. Dissertation. 65 pages, bibliography 55 citations. In Latvian. VETERINARY DRUGS. GAS CHROMATOGRAPHY. HIGH PERFORMANCE LIQUID CHROMATOGRAPHY, MASS SPECTROMETRY. LEVAMIZOLE, STEROID SUBSTANCES, ANTIBIOTICS, NSAID GROUP COMPOUNDS. This dissertation is dealing with determination of veterinary drug residues using masspectrometric methods. Survey of publications dealing with analysis of levamisole, nonsteroid anti-inflammatory drugs, steroid compounds and sulphonamides was performed. Masspectrometric methods for determination of residues of 33 different compounds are elaborated. Ma…

Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS

2009

10 páginas, 2 figuras, 4 tablas.

Determination of pesticides and veterinary drug residues in food by liquid chromatography-mass spectrometry: A review

2015

Monitoring of pesticides and veterinary drug residues is required to enforce legislation and guarantee food safety. Liquid chromatography-mass spectrometry (LC-MS) is the prevailing technique for assessing both types of residues because LC offers a versatile and universal separation mechanism suitable for non-gas chromatography (GC) amenable and the majority of GC-amenable compounds. This characteristic becomes more relevant when LC is coupled to MS because the high sensitivity and specificity of the detector allows to apply generic sample preparation procedures, which simultaneously extract a wide variety of residues with different physico-chemical properties. Determination of metabolites …

Emerging Contaminants

2015

Brominated flame retardants (BFRs), compounds formed during food processing, mycotoxins, perfluoroalkyl substances (PFASs), pesticides, phycotoxins, polycyclic aromatic hydrocarbons (PAHs), and veterinary drugs are considered environmental emerging contaminants of particular concern. This chapter reviews the most important groups of emerging contaminants as well as the analytical platforms based on mass spectrometry (MS) developed to determine their presence in food. MS instruments utilize many different types of mass analyzers to improve selectivity and also confidence in assigning the identity of these emerging pollutants. Current analytical approaches are discussed together with the majo…

Veterinary drug residues in meat: Concerns and rapid methods for detection.

2007

The use of substances having hormonal or thyreostatic action as well as β-agonists is banned in the European Union. However, sometimes forbidden drugs may be added to feeds for illegal administration to farm animals for promoting increased muscle development or increased water retention and thus obtain an economical benefit. The result is a fraudulent overweight of meat but, what is worse, residues of these substances may remain in meat and may pose a real threat to the consumer either through exposure to the residues, transfer of antibiotic resistance or allergy risk. This has exerted a great concern among European consumers. The control of the absence of these forbidden substances in anim…

Wide-range screening of banned veterinary drugs in urine by ultra high liquid chromatography coupled to high-resolution mass spectrometry

2012

In this work, an ultra high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) methodology is proposed for the multi-class multi-residue screening of banned and unauthorized veterinary drugs in bovine urine, using an Orbitrap Exactive™ analyzer working at a resolving power of 50,000 FWHM in full scan, both in positive and negative mode. The method currently covers 87 analytes belonging to different families such as steroid hormones, β-agonists, resorcylic acid lactones (RAL), stilbens, tranquillizers, nitroimidazoles, corticosteroids, NSAIDs, amphenicoles, thyreostatics and other substances such as dapsone. A database including the elemental composition, the po…

Veterinary Drugs and Growth Promoters Residues in Meat and Processed Meats

2009

Development and optimization of confirmatory liquid chromatography—Orbitrap mass spectrometry method for the determination of 17 anticoccidials in po…

2018

A new sensitive and selective multi-residue method based on liquid chromatography - Orbitrap high resolution mass spectrometry (LC-Orbitrap-HRMS) was developed and validated for the determination of 17 anticoccidials in poultry and eggs. Instrumental parameters were optimized by the means of statistical experimental designs to improve the sensitivity, precision, and repeatability of the method. Further optimization of auto-tuned MS parameters led to an increase of signal intensity by 10% to 99% for 16 out of 17 analytes. The sample preparation procedure included extraction from muscle tissue and egg samples with acetonitrile, followed by preconcentration, reconstitution, and filtration. Val…

Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: potential application to quantitati…

2014

Abstract Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a screening method covering 116 human and veterinary drugs has been developed and validated in five types of animal feed at 0.02 and 0.2 mg kg−1. After a simple extraction and dilution, the samples were analysed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). Nearly all compounds tested were detected at 0.02 mg kg−1, based on the presence of the accurate-mass (de)protonated molecule. However, the identification using a…